A classic March Madness matchup of a mid-major facing a Power-5 program will take place Friday as the No. 1 Morehead State Eagles look for the upset against the No. 3 West Virginia Mountaineers. Tip-off is from Indianapolis at 9:50 p.m. ET and the winner of this first-round matchup will then play the winner of No. 6 San Diego State vs. No. 11 Syracuse. 

William Hill Sportsbook lists WVU as 13-point favorites in the latest West Virginia vs. Morehead State odds, and the Over-Under for total points is 136 (for the latest college basketball lines for all of today's games, head over to our college basketball odds page).

Before making any Morehead State vs. West Virginia picks, you MUST check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,500 for $100 players on its top-rated college basketball picks against the spread. It has also returned almost $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen HUGE returns.

Now, it has broken down West Virginia vs. Morehead State, and we can tell you the model is leaning Over the total. It also says one side of the spread hits over 50 percent of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins West Virginia vs. Morehead State? And which side of the spread hits well over 50 percent of the time? ... Join SportsLine right now to find out which side of the Morehead State vs. West Virginia spread you should be all over Friday, all from the model up more than $2,500 on its top-rated college basketball picks over the past four seasons!