The marquee matchup on the Week 10 college football schedule will pit No. 4 Ohio State against No. 3 Penn State. The path to the College Football Playoff will be virtually paved in gold for the winners while the losers will have to grind through the rest of a difficult Big Ten schedule and then leave their fates in the hands of the CFP committee. The Buckeyes are listed as 3.5-point road favorites in the latest Week 10 college football odds. 

So which side should you be backing in that game and how should you be handling every Week 10 college football spread? Before you make any Week 10 college football picks, be sure to check out the college football score predictions from the SportsLine AI PickBot.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has nailed 1,947 4.5- and 5-star prop picks since the start of last season! Anyone who has followed it is WAY UP!

Now, it has turned its attention to the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 10 game, and the results are in. 

We can tell you the AI PickBot likes the No. 18 Pitt Panthers (+7.5, 58.5) to cover on the road against the No. 20 SMU Mustangs in an 8 p.m. ET kickoff on Saturday. Both teams are unbeaten in conference play and in College Football Playoff contention with the winner of the ACC earning an automatic bid. However, Pitt has been the far superior team against the spread, going 6-1 against the number while SMU is just 4-3.

The AI PickBot has also made exact score predictions in every other FBS matchup, including another dozen A-rated spread picks!

So what are the scores for every college football game in Week 10, and which A-rated spread picks should you be all over? ... Join SportsLine now to see who wins and covers every single game, all from the AI model that has nailed 1,947 of its top-rated NFL prop picks since its inception! ... You've unlocked our best deal! Get your first month of SportsLine for ONLY $1 with the promo code "LEAGUE"! Join here!