Wednesday in MLB: Will White Sox stay red-hot at home?

Two starters who have struggled despite their clubs' otherwise solid starts face each other Wednesday when the White Sox host the Red Sox.

Boston's Clay Buchholz (0-3, 6.51 ERA) has endured a continuation of what has become a tradition of early-season misery.

He has yet to register a win while giving up at least five earned runs in four of his five starts, including five runs and four walks in a 5-3 home loss to the Braves in his last outing.

Buchholz is 14-16 with an ERA of 4.91 in 39 career April starts, which includes a 1-3 mark with a 5.76 ERA last season.

"I wouldn't ever go on a bad streak if I knew what I had to do not to go on them," he said. "I think it just happens sometimes. The team is going good and everybody is throwing the ball well, and it's falling on me right now."

Buchholz is 2-3 with a 4.25 ERA in eight career starts against the White Sox, who have won three straight after taking the series opener 4-1 Tuesday.

Chicago starter Carlos Rodon (1-3, 4.33 ERA) has had his own problems, as he gave up six runs on eight hits in a 6-3 loss to the Orioles in his last outing.

Rodon is 0-2 in his last three starts with a 7.07 ERA.

Oddsmakers give Chicago a slight edge, as the White Sox are favored in the -110 range at most outlets. Get SportsLine's pick by clicking here.

Last night on SportsLine: The SportsLine Projection Model enjoyed a 4-2 mark on top-rated MLB side selections as it notched winners with the Dodgers, Giants, Orioles and Blue Jays.  

SportsLine is now 35-46 on A-rated picks for the season (43.2 percent), while B-level selections are 64-67 (48.9 percent, 1-2 on Tuesday) and C-rated recommendations are 91-91 (50 percent, 3-3).

Top-rated MLB total selections are 20-24 (45.5 percent) after going 1-2 Tuesday, while B-rated totals are 63-60 (51.2 percent, 3-4) and C-level selections are 88-97 (47.6 percent, 3-2).

SportsLine has four A-rated side selections and two top-rated totals available for Wednesday.

Get all of the picks by clicking here.

The analyst says: SportsLine handicapper Matty Simo is on an 8-2 run with his MLB selections after splitting a pair of totals Tuesday.

Simo and fellow SportsLine analysts Larry Hartstein and Josh Nagel will have MLB selections for Wednesday's card.

Trends to note: The Mariners have won six straight games in Oakland and six of their last seven road games overall. ... The Under is on a 4-1 run between the Mariners and Athletics. ... The Padres have won five of their last six meetings with the Rockies. ... The Rockies have won four straight road starts by Tyler Chatwood. ... The Tigers are 6-1 in their last seven games against right-handed starters. ... The Indians are 1-4 in the last five starts by Corey Kluber. ... The Under is on a 6-0 run in Rangers' road games. ... The Marlins are 6-0 against NL West opponents. ... The Diamondbacks are 5-1 in their last six road games. ... The Dodgers have won four straight road games against left-handed starters. ... The White Sox are 7-1 in their last eight games following a win.

Injuries to watch: Cubs left fielder Matt Szczur was placed on the 15-day disabled list with strained right hamstring. ... Mariners pitcher Tony Zych is on the 15-day disabled list with right rotator cuff tendinitis. ... Orioles shortstop J.J. Hardy is out indefinitely with a fractured left foot. ... Indians catcher Roberto Perez was put on the 15-day disabled list with a fractured right thumb. ... Phillies pitcher Dalier Hinojosa was placed on the 15-day disabled list with a right hand contusion. ... Giants second baseman Joe Panik is listed as day-to-day with a groin injury. ... Indians first baseman Mike Napoli is day-to-day with a neck injury. ... Reds catcher Devon Mesoraco is day-to-day with shoulder stiffness.