Head coach Deion Sanders and the Colorado Buffaloes (4-6, 1-6 Pac-12) hit the road looking to snap a four-game losing streak when they travel to Pullman, Wash. to take on the Washington State Cougars (4-6, 1-6 Pac-12) on Friday night. Kickoff at Gesa Field is scheduled for 10:30 p.m. ET. The Buffs are coming off a 34-31 loss to Arizona on a walk-off field goal, while the Cougars, who have lost six straight, are looking to bounce back from a 42-39 loss to Cal. Quarterback Shedeur Sanders continues to play well for CU, but has been sacked 49 times in 2023. Colorado is 6-3-1 and Washington State is 4-5 against the spread this season.

The Cougars are 4-point favorites in the latest Colorado vs. Washington State odds via SportsLine consensus, while the over/under for total points scored is 59.5. Washington State is a -188 (risk $188 to win $100) favorite on the money line, with Colorado listed at +157 (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Colorado vs. Washington State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, including a 5-1 mark in the CU vs. USC game and a 3-1 record in last week's Colorado-Arizona matchup. Overall, he's on a 59-23-2 roll on his college football best bets for SportsLine this season so far! He went 8-1 on his CFB Week 11 picks, returning a profit of $690 for $100 bettors. Anyone who has followed his picks this season is WAY UP!

Kaylor knows the Buffs are desperate for a win after getting off to a hot start to the 2023 season. The Buffs have lost, but covered in their last three contests and quarterback Shedeur Sanders continues to get hit and sacked at an alarming rate. Sanders has now been sacked 49 times, which is the second most in college football. Travis Hunter continues to play at a very high level on both sides of the ball.

Kaylor, however, also factored in that Washington State is also desperate for a win after opening the season 4-0. The Cougars have lost six straight, and their streak of seven straight bowl games (not counting the COVID shortened 2020 season) would come to an end with a loss on Friday night. Quarterback Cameron Ward is one of the top quarterbacks in the Pac-12 this season.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Washington State. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates

Who wins Colorado vs. Washington State on Friday in a battle between teams looking to keep their bowl eligibility alive, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Washington State vs. Colorado spread to jump on, all from the expert who is on a 59-23 roll on his college football picks this season, and find out!