The Virginia Cavaliers will try to bounce back from a season-opening loss to Tennessee when they face the James Madison Dukes on Saturday afternoon. Virginia trailed 21-3 at halftime of its 49-13 loss to the Vols. James Madison opened the season with a 38-3 win over FCS Bucknell, failing to cover the 46.5-point spread. 

Kickoff is set for noon ET on Saturday at David A. Harrison III Field at Scott Stadium. James Madison is favored by 6 points in the latest Virginia vs. James Madison odds, while the over/under is set at 40.5 points, per SportsLine consensus. 

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The model has simulated Virginia vs. James Madison 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

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