The Virginia Cavaliers try to make a climb in the ACC when they host the Duke Blue Devils at 12:30 p.m. ET on Saturday at David A. Harrison III Field at Scott Stadium. Virginia's only two looses this season come from conference play, and Duke is looking for its first win in the month of October.

Virginia is 4-2 overall and 2-1 at home, while Duke is 3-3 overall and 0-2 on the road. Virginia QB Brennan Armstrong has thrown for the most yards in all of college football. The Cavaliers are favored by 10.5 points in the latest Virginia vs. Duke odds from Caesars Sportsbook and the over-under is set at 69.5. Before you make any Duke vs. Virginia picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Virginia vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Virginia vs. Duke? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks ... If you're already a member, see the picks below!