The Virginia Tech Hokies will take on the No. 14 Notre Dame Fighting Irish at 7:30 p.m. ET on Saturday at Lane Stadium/Worsham Field. The Hokies are 3-1 overall and 3-0 at home, while Notre Dame is 4-1 overall and 1-0 on the road. 

The latest Notre Dame vs. Virginia Tech odds list this game as a pick'em, and the over-under is set at 47. Before you make any Notre Dame vs. Virginia Tech picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Virginia Tech vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Virginia Tech vs. Notre Dame? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!