Supremacy in the Big East will be on the line when the conference's top two teams -- the No. 10 Villanova Wildcats and the No. 14 Creighton Bluejays -- collide in a crucial showdown on Wednesday at Finneran Pavilion in Villanova, Pa. Tip-off is set for 8:30 p.m. ET. The Wildcats are favored by 4.5-points in the latest odds from William Hill Sportsbook, while the Over/Under for total points scored is 146.5. (See up-to-date odds for every game this week on our college basketball odds page.) 

Before making any Villanova vs. Creighton picks, be sure to check out what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every Div. I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of more than $2,600 for $100 players on its top-rated college basketball picks against the spread. It has also returned more than $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Creighton vs. Villanova. We can tell you that the model is leaning Over the total, and it also says one side of the spread hits in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Villanova vs. Creighton? And which side of the spread hits over 50 percent of the time? ... Join SportsLine right now to find out which side of the Creighton vs. Villanova spread you should be all over Wednesday, all from the model on a roll on college basketball picks!