The Week 10 NFL schedule features a cross-conference battle between two teams with Super Bowl aspirations when Josh Allen and the Buffalo Bills (6-2) host Kirk Cousins and the Minnesota Vikings (7-1) at Highmark Stadium in Buffalo. The Bills are hoping to rebound from a disappointing 20-17 loss to the New York Jets, while the Vikings are looking to extend their winning streak to seven games after knocking off the Washington Commanders 20-17 in Week 9. Buffalo is 4-3-1 against the spread, while Minnesota is 3-4-1 ATS in 2022. Allen is dealing with an elbow injury that has him as questionable for Sunday. 

Kickoff is at 1 p.m. ET. Buffalo is favored by 6.5 points in the latest Bills vs. Vikings odds from Caesars Sportsbook, and the over/under is set at 46.5 points. Before making any Vikings vs. Bills picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Bills vs. Vikings 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits well over 50% of the time. You absolutely need to see it before locking in your own picks.

So who wins Vikings vs. Bills? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.