The Vanderbilt Commodores will take on the Loyola Chicago Ramblers at 8:00 p.m. ET on Friday at Memorial Gym. The Commodores are 5-3 overall and 4-2 at home, while Loyola Chicago is 8-2 overall and 1-0 on the road. 

The Ramblers are favored by 4.5 points in the latest Vanderbilt vs. Loyola Chicago odds from Caesars Sportsbook, and the over-under is set at 132. Before you make any Loyola Chicago vs. Vanderbilt picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Vanderbilt vs. Loyola Chicago 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Vanderbilt vs. Loyola Chicago? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.