The UTSA Roadrunners will take on the No. 24 Houston Cougars at 3:30 p.m. ET on Saturday at the Alamodome on CBS Sports Network. This is the only Week 1 matchup that features a pair of 12-win teams from last season. The Cougars are favored by four points in the latest UTSA vs. Houston odds from Caesars Sportsbook, and the over/under is set at 62. 

Before you make any Houston vs. UTSA picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated UTSA vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins UTSA vs. Houston? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.