It's another critical matchup between the fierce rivals when the United States Men's National Team hosts Mexico on Friday in a 2022 Concacaf World Cup Qualifying match in Cincinnati, Ohio. Mexico (4-2-0) leads third-round qualifying, but Team USA (3-2-1) has won the last two meetings. 

Kickoff is set for 9 p.m. ET at TQL Stadium. The latest USMNT vs. Mexico odds from Caesars Sportsbook list USA as the slight +163 favorite (risk $100 to win $163) on the 90-minute money line, while Mexico is the +175 underdog. A draw is priced at +180, and the over-under for total goals scored is 2.5. (For the latest soccer news and analysis, click here)

Proven soccer expert Martin Green has identified his best bets for the USMNT vs. Mexico matchup below, and bettors who have followed his advice have cashed in huge. Green is a handicapper who has covered the game worldwide, and his European soccer picks have generated more than $36,000 for $100 bettors since the 2017-18 season.

The Americans beat El Tri in extra time in both the Gold Cup and Nations League finals this summer, so they come in with confidence. They are 14-2-0 in their last 16 matches in U.S. soil. They have some injuries, with Gio Reyna and Sergino Dest out, but Christian Pulisic, who has 16 goals in 40 international matches, is back from injury. Playmaking forward Brenden Aaronson, who has five career goals, and midfielders Sebastien Llletget (eight) and Weston McKennie (seven) also can cause trouble.                

Mexico has no significant injuries, and it has talent to spare. There is plenty to fear in the attack, with Raul Jimenez (28 international goals), Hirving Lozano (15) and Jesus Corona (15) joined by Liga MX stars Rogelio Funes Mori and Henry Martin. Midfielders Andres Guardado (28 career goals), Hector Herrera and Edson Alvarez are the engine of the potent attack. The Americans haven't won three straight games in the history of the series, and El Tri holds a 36-15-21 advantage all-time.      

Green has taken a close look at the USMNT vs. Mexico matchup from every angle, and he is leaning Over on the goal total. He also has two CONFIDENT best bets, both offering plus-money payouts, and a full breakdown of the match! You ABSOLUTELY need to see his picks and analysis before making any selections of your own.

What are the best bets you can make on the USMNT vs. Mexico match on Friday? And which wager should you be all over if you want to cash in BIG?  ... Join SportsLine now to see Martin Green's best bets on Friday's USMNT vs. Mexico World Cup Qualifier, all from the soccer insider who's generated more than $36,000 for $100 bettors since the 2017-18 season!