The UCLA Bruins (6-4, 4-3 Pac-12) were one of college football's most intriguing teams early this season, but now find themselves behind two teams in the Pac-12 South, and just ahead of Saturday's opponent, USC (4-5, 3-4). Since moving on from Clay Helton after a lackluster 1-1 start this season, Donte Williams hasn't fared much better for the Trojans, who have gone 3-4 since the switch. USC won last year's meeting between the two, and the teams combined for nearly 1,000 yards of offense.

Kickoff is set for 4 p.m. ET from United Airlines Field at the Los Angeles Memorial Coliseum, where UCLA has won just once since 2001. The Bruins are favored by three points in the latest USC vs. UCLA odds from Caesars Sportsbook, and the over-under is set at 65.5. Before you make any UCLA vs. USC picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated USC vs. UCLA 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins USC vs. UCLA? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks ... If you're already a member, see the picks below!