The USC Trojans will take on the Fresno State Bulldogs at 10:30 p.m. ET on Saturday at United Airlines Field at the Los Angeles Memorial Coliseum. The Trojans are 2-0 while Fresno State is 1-1. Fresno State suffered a last second home loss to Oregon State last week while USC beat Stanford on the road handily. 

The Trojans are favored by 12 points in the latest USC vs. Fresno State odds from Caesars Sportsbook, and the over/under is set at 73.5. Before you make any Fresno State vs. USC picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns.

Now, it has simulated USC vs. Fresno State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins USC vs. Fresno State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.