Coach Deion Sanders and the Colorado Buffaloes (3-1) look to bounce back from a humbling 42-6 loss to No. 9 Oregon when they take on reigning Heisman Trophy winner Caleb Williams and the No. 8 USC Trojans (4-0) on Saturday at Folsom Field in Boulder, Colo.. Buffs quarterback Shedeur Sanders aims to get back into the Heisman Trophy conversation with a strong performance against USC. The Trojans defeated Arizona State 42-28 las Saturday behind five touchdowns from Williams. Both teams are 2-2 against the spread this season. Two-way standout Travis Hunter remains out for CU after suffering a liver injury against Colorado State. Safety Shilo Sanders is listed as questionable after suffering an injury against Oregon.

After opening at -24.5, the Trojans are 22.5-point favorites in the latest Colorado vs. USC odds via SportsLine consensus, while the over/under for total points scored is down to 73 after opening at 73.5. USC is a -1628 favorite on the money line, with Colorado listed at +883 (see up-to-date odds for every game this week on our college football odds page).

Before you make any Colorado vs. USC picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, going 6-2 on his best bets in the Buffs' first four games of the season. He's also 9-2 on all his CFB best bets this season so far! Anyone who has followed his picks is WAY UP!

Kaylor knows that some weaknesses in the Buffs' roster have been exposed over the past two weeks in their games with Colorado State and Oregon. He's also considered that junior quarterback Shedeur Sanders is one of the best players in the country. The Buffs face a porous USC defense this week that has given up an average of 20 points per game while playing against San Jose State, Nevada, Stanford and Arizona State. 

Kaylor, however, factored in that USC is as explosive as any team in the country on the offensive side of the ball. Led by reigning Heisman Trophy winner Caleb Williams, the Trojans average 569.3 yards of total offense and 55 points per game. Colorado allows an average of 33.3 points and 475.8 yards per game, and has yet to face an offense with USC's ability. 

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. USC. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Colorado vs. USC in the first Pac-12 home game for Deion Sanders on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the USC vs. Colorado spread to jump on, all from the expert who is on a 6-2 roll betting on Colorado games this season, and find out!