The No. 5 USC Trojans look to continue their perfect start to the 2023 season as they head to Tempe to face Pac-12 rival, the Arizona State Sun Devils. The Trojans are 3-0, having outscored their opponents 178-52 and enter off a bye in Week 3. ASU lost at home to Fresno State, 29-0, dropping their record to 1-2. The Trojans won this matchup last season in Los Angeles, 42-25. Kickoff is set for 10:30 p.m. ET at Mountain America Stadium in Tempe. 

The Trojans are 35-point road favorites, while the over/under is set at 62 (see up-to-date odds for every game this week on our college football odds page) in the latest Arizona State vs. USC odds. 

Before making any USC vs. Arizona State picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that USC is led by the reigning Heisman Trophy winner, quarterback Caleb Williams, who has thrown for 878 yards and 12 touchdowns thus far this season. The Trojans have the top offense in the country thus far, averaging more than 580 yards per game thus far in 2023, though their opponents are gaining more than 368 against USC's defense.

The model also knows that Arizona State is struggling with injuries and might be forced to start fourth string QB Jacob Conover, who struggled in last week's loss to the Bulldogs. New coach Kenny Dillingham's team is only averaging 13 points per game, among the worst offenses statistically in FBS competition this season.

Now, it has set its sights on USC vs. Arizona State. We can tell you the model is leaning Over on the point total, and it also says one side of the spread hits in approximately 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Arizona State vs. USC, and which side of the spread hits in approximately 50% of simulations? Join SportsLine right now to find out which side of the USC vs. ASU spread you should be all over, all from the model that's up nearly $2,500 on top-rated CFB spread picks since its inception!