Lightweight champion Islam Makhachev will defend his title on Saturday against veteran contender Dustin Poirier in the main event of UFC 302. The main UFC 302 fight card is set for 10 p.m. ET at the Prudential Center in Newark, New Jersey. Makhachev is a -625 favorite (risk $625 to win $100), while Poirier is a +450 underdog (risk $100 to win $450) in the latest UFC 302: Makhachev vs. Poirier odds. Before making any UFC 302: Makhachev vs. Poirier picks, make sure you see the MMA predictions and betting advice from SportsLine expert Daniel Vithlani.

Vithlani is a highly analytical UFC bettor who has been a consistent winner for SportsLine members since making his debut in January 2023 with a 5-0 record for UFC 283. In the last 11 UFC pay-per-view events, Vithlani has gone 7-4 on main-event picks and his main-card selections in that span have netted his followers a profit of more than $1,200. 

His highlights include calling an upset for Sean O'Malley (+210) against Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card and his UFC 299 winners included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). Anyone who has followed him is WAY UP!

This week at UFC 302: Makhachev vs. Poirier, we can tell you Vithlani is picking Kevin Holland (-265) to get past Michal Oleksiejczuk (+215) in a battle of bruising middleweights. "Holland has long-range boxing, toughness, cardio and is now seasoned with grappling experience," Vithlani told SportsLine.

Vithlani has strong picks for Makhachev vs. Poirier and other bouts on the UFC 302 card. He's also backing a fighter who "has a granite chin and lethal body kicks" to emerge with a dominant victory! You ABSOLUTELY need to see his UFC 302 picks before making any of your own!

Who wins UFC 302: Makhachev vs. Poirier, and which fighter is a MUST-BACK? Join SportsLine now to see which fighters you need to be all over Saturday, all from the expert  who profited more than $1,500 in UFC main-card picks!