Two title fights will anchor the final UFC pay-per-view card of 2021 as lightweight champion Charles Oliveira defends his title against top-ranked contender Dustin Poirier in the main event of UFC 269 on Saturday. The main UFC 269 fight card is set for 10 p.m. ET from T-Mobile Arena in Las Vegas.

Poirier is a -160 betting favorite (risk $160 to win $100), while Oliveira is priced at +140 (risk $100 to win $140) in the latest UFC 269 odds from Caesars Sportsbook. In the co-main event, women's bantamweight champion Amanda Nunes (-800) takes on rising contender Julianna Pena (+575) in another title fight. 

Before making any UFC 269: Oliveira vs. Poirier picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past 33 months, $100 bettors who have followed Marley's picks are up more than $13,000! 

The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 42 of his last 70 UFC main-event picks, a stretch that included a streak of five consecutive underdogs in 2020! At UFC 268, his winners included calling Rose Namajunas (-105) to win her rematch against Weili Zhang (-115) for the women's strawweight title in the co-main event. Anyone who has followed him is WAY UP! 

This week at UFC 269: Oliveira vs. Poirier, we can tell you Marley is backing Dominick Cruz (-105) to get his hand raised against Pedro Munhoz (-115) in a matchup of bantamweight contenders. He's also backing a fighter who is "levels ahead of their opponent" to emerge with a dominant victory! You ABSOLUTELY need to see Marley's other UFC 269 picks before making any of your own.

Who wins Oliveira vs. Poirier? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $13,000 on MMA picks!