Kamaru Usman will make the fifth defense of his welterweight title on Saturday against top-rated contender Colby Covington in the main event of UFC 268. The rematch, two years in the making, closes the curtain on the main UFC 268 fight card, which is scheduled for a 10 p.m. ET start.

Usman is a -290 favorite (risk $290 to win $100), while Covington is a +245 underdog (risk $100 to win $245) in the latest Usman vs. Covington odds at Caesars Sportsbook.

Before making any UFC 268 picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past 33 months, $100 bettors who have followed Marley's picks are up more than $14,000!  

The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 39 of his last 66 UFC main-event picks, a stretch that included a streak of five consecutive underdogs in 2020! Last week at UFC 268, his winners included calling a victory for Amanda Ribas (-160) against Virna Jandiroba (+140) in a matchup of women's strawweight contenders. Anyone who has followed him is WAY UP! 

Usman made his first title defense against Covington in December 2019 and retained the crown with a fifth-round stoppage. He has since made three other title defenses, but many MMA observers believe Covington is the most legitimate threat to his title among current contenders, and their rematch has long been anticipated.

What's more, UFC president Dana White has repeatedly said that he believes their first matchup is among the best fights he has ever witnessed. This is because both world-class wrestlers left their takedowns in the locker room in exchange for an all-out slugfest that saw both combatants give and take their share of serious damage.

Usman (19-1) and Covington (16-2) also have a personal rivalry that was instigated by the challenger's relentless insults toward the champion, including allegations of steroid use. 

This week at UFC 268, we can tell you Marley is backing Edmen Shahbazyan (+105) to upset Nassourdine Imamov (-125) in a battle of middleweight prospects. He's also backing a fighter who "is faster and the better striker" to emerge with a dominant victory! You ABSOLUTELY need to see Marley's other UFC 268 picks before making any of your own.

Who wins Usman vs. Covington 2? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $14,000 on MMA picks!