Heavyweights will top the bill at UFC 265 on Saturday as veteran contender Derrick Lewis takes on undefeated prospect Ciryl Gane  Gane in the main event. The main UFC 265 fight card from the Toyota Center in Houston is set for 10 p.m. ET.

Gane (9-0) is considered a prodigal talent whose versatility and athleticism have many MMA observers believing he could be a long-reigning heavyweight champion. He can get a piece of the title by defeating Lewis (25-7-1), who holds the UFC heavyweight record for knockouts with 12.

The winner will move on to face daunting champion Francis Ngannou, who was originally scheduled to fight on this card but informed the promotion he would not be ready for an early August fight.

Gane is a -380 favorite (risk $380 to win $100), while Lewis is offered at +310 (risk $100 to win $310) in the latest Caesars Sportsbook MMA odds for UFC 265.

Before making any UFC 265 picks of your own, you NEED to see the latest MMA predictions from SportsLine MMA analyst Kyle Marley. Over the past 30 months, $100 bettors who have followed Marley's picks are up more than $14,000. 

The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 34 of his last 56 UFC main-event picks, a stretch that included a streak of five consecutive underdogs!

At UFC Fight Night last weekend, Marley's winners included calling a five-round decision victory for Sean Strickland (-210) against Uriah Hall (+190) in the middleweight main event. Anyone who has followed Marley is WAY UP! 

This week at UFC 265, we can tell you Marley is backing Tecia Torres (-135) to get her hand raised against Angela Hill (+115) in a matchup of veteran strawweight contenders on the main card.

Now, Marley has made the call on Lewis vs. Gane and every other fight on the UFC 265 docket. He's also taking a fighter who will lead in volume to score an upset, sending his backers straight to the payout window! You ABSOLUTELY need to see Marley's other UFC 265 picks before making any of your own.

Who wins Gane vs. Lewis and every bout on the UFC 265 card? And which fighter is a MUST-BACK? ... Join SportsLine right now to see which fighters you need to be all over Saturday, all from the expert who's up more than $14,000 on MMA picks!