Head coach Deion Sanders and the Colorado Buffaloes (4-3, 1-3 Pac-12) look to bounce back from a highly disappointing loss to Stanford when they hit the road to take on the No. 22 UCLA Bruins (5-2, 2-2 Pac-12) at the Rose Bowl on Saturday. CU quarterback Shedeur Sanders continued his stellar campaign, throwing for 400 yards, five touchdowns, and one interception in the Buffs' 46-43 double overtime loss to the Cardinal. The Buffs are coming off a bye and should be well rested for this matchup. UCLA is coming off a dominant 42-7 win over Stanford on Oct. 21. The Bruins are 3-3 and the Buffs are 3-3-1 against the spread in 2023.

The Bruins are 15-point favorites in the latest Colorado vs. UCLA odds via SportsLine consensus, while the over/under for total points scored is 60. UCLA is a -695 (risk $695 to win $100) favorite on the money line, with Colorado listed at +478 (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Colorado vs. UCLA picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, going 15-6 on his best bets in the Buffs' first seven games, including a 5-1 mark in the CU vs. USC game. He's also 33-12-2 on all of his CFB best bets this season so far! Anyone who has followed his picks is WAY UP!

Kaylor know some weaknesses in the Buffs' roster have been exposed over the past six weeks that have put a bit of a damper on the program's electric start to the Coach Prime era. Quarterback Shedeur Sanders remains one of the most productive players in college football, and two-way standout Travis Hunter is a force on both sides of the ball. The Buffs are coming off a collapse against Stanford, but had a bye week to prepare for this matchup. 

Kaylor, however, also factored in that UCLA is playing extremely well on both sides of the ball under head coach Chip Kelly. The Bruins have a balanced offensive attack, and rank ninth in the country in rushing yards per game (215.6). Defensively, UCLA is stout and has the talent up front to keep constant pressure on Shedeur Sanders.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. UCLA. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Colorado vs. UCLA in the Buffs' first game against the Bruins under coach Deion Sanders on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the UCLA vs. Colorado spread to jump on, all from the expert who is on a 15-6 roll betting on Colorado games this season, and find out!