The UCF Knights attempt to get off to a 2-0 start for the sixth consecutive season when they host the Louisville Cardinals on Friday. UCF (1-0) opened the 2022 campaign with a 56-10 home victory against South Carolina State, while Louisville (0-1) suffered a 31-7 loss at Syracuse in its opener. The Cardinals defeated the Knights 42-35 at home last year to take a 2-1 lead in the all-time series. Kickoff from FBC Mortgage Stadium in Orlando, Fla. is set for 7:30 p.m. ET.

The Knights are 6-point favorites in the latest UCF vs. Louisville odds from Caesars Sportsbook, while the over/under for total points scored is 61.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you consider your Louisville vs. UCF picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns.

The model knows UCF's offense recorded seven touchdowns in the season opener, with John Rhys Plumlee producing a total of five in his team debut. The transfer from Ole Miss threw for 308 yards and four scores while rushing for 86 yards and a TD. Senior running back Isaiah Bowser ran for the other two touchdowns as he racked up 109 (83 rushing) of the Knights' 600 total yards in the victory.

The model also knows Louisville quarterback Malik Cunningham failed to throw or run for a touchdown against Syracuse, ending his streak of 30 consecutive games with a score. The senior set the school record for starts by a signal-caller (39) last week and will establish another mark Friday as he makes his 37th in a row. Running back Tiyon Evans and wide receiver Tyler Hudson had solid debuts after transferring from Tennessee and Central Arkansas, respectively, with the former rushing for 89 yards and a TD and the latter making eight catches for 102 yards.

Now the model has simulated UCF vs. Louisville 10,000 times, and the results are in. We can tell you that the model is leaning Over on the total, and it also says one side of the spread hits almost 70% of the time. You ABSOLUTELY need to see it before locking in your own picks.

Who wins the UCF vs. Louisville matchup on Friday? And which side of the spread hits almost 70% of the time? ... Join SportsLine right now to see which side of the Louisville vs. UCF spread you need to jump on Friday, all from the computer model that is on a 48-37 run on its top-rated college football picks!