Tyson Fury puts his WBC heavyweight title on the line Saturday against Deontay Wilder in a trilogy matchup that should settle one of the sport's most heated rivalries in recent memory. The pay-per-view card is slated for a 9 p.m. ET start from T-Mobile Arena in Las Vegas.

The fighters have just one combined professional loss between them. That blemish belongs to Wilder (42-1-1), who was outclassed by Fury (30-0-1) in their February 2020 rematch and stopped in the seventh round.

However, Wilder floored Fury twice in their inaugural meeting in December 2018, but had to settle for a split draw on the scorecards. That memorable encounter led to an inevitable rematch and, ultimately, Saturday's third showdown between the rivals. 

Fury is a -280 favorite (risk $280 to win $100), while Wilder is priced at +230 (risk $100 to win $230) in the latest Caesars Sportsbook boxing odds for Fury vs. Wilder III. Before settling any picks of your own for Fury vs. Wilder III, make sure you check out the predictions and betting advice from SportsLine combat analyst Brandon Wise. 

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing analyst. His strong 2021 boxing record includes correctly calling victories for social-media-star-turned-boxing-phenom Jake Paul over former UFC fighters Ben Askren and Tyron Woodley. Moreover, the respected combat analyst also called Jamel Herring (+105) to defeat Carl Frampton (-125) for the WBO junior lightweight title in April. Anyone who has followed Wise's combat sports picks is WAY UP! 

What's more, Wise also has been on point with his UFC predictions this year. He called Israel Adesanya by decision against Marvin Vettori at +140 and Brandon Moreno to win outright against Deiveson Figueiredo+190 at UFC 263 earlier this summer.

Now, with Saturday's showdown fast approaching, Wise has studied Fury vs. Wilder III from every angle, identified the best value in the boxing odds and released his confident picks. Wise specializes in prop bets and he's locked in several plus-money options, including one that returns around 9-1! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Fury vs. Wilder III on Saturday night? And which prop is a MUST-BACK? ... Join SportsLine here to see which bets you need to make for Saturday's big fight, all from the accomplished combat sports analyst who has been profitable every year!