The long-awaited trilogy fight between Tyson Fury and Deontay Wilder is finally set to take place Saturday night at T-Mobile Arena in Las Vegas. The pay-per-view portion of the card is set for 9 p.m. ET.

The combatants saw their rivalry begin with an action-packed draw nearly three years ago that saw Wilder (42-1-1) retain the WBC heavyweight title. Their rematch in February 2020 was a different story, as Fury (30-0-1) took the belt behind a dominant performance that ended in a seventh-round finish.

Their third and likely final showdown comes at the end of myriad logistical delays and even an element of litigation as Wilder took Fury to court in order to have his rematch clause honored. Now, the boxers will settle their differences in the ring. 

Fury is a -280 favorite (risk $280 to win $100), while Wilder is priced at +230 (risk $100 to win $230) in the latest Caesars Sportsbook boxing odds for Fury vs. Wilder III. Before settling any picks of your own for Fury vs. Wilder III, make sure you check out the predictions and betting advice from SportsLine combat analyst Brandon Wise. 

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing analyst. His strong 2021 boxing record includes correctly calling victories for social-media-star-turned-boxing-phenom Jake Paul over former UFC fighters Ben Askren and Tyron Woodley. Moreover, the respected combat analyst also called Jamel Herring (+105) to defeat Carl Frampton (-125) for the WBO junior lightweight title in April. Anyone who has followed Wise's combat sports picks is WAY UP! 

What's more, Wise also has been on point with his UFC predictions this year. He called Israel Adesanya by decision against Marvin Vettori at +140 and Brandon Moreno to win outright against Deiveson Figueiredo+190 at UFC 263 earlier this summer.

Now, with Saturday's showdown fast approaching, Wise has studied Fury vs. Wilder III from every angle, identified the best value in the boxing odds and released his confident picks. Wise has made the call on which fighter wins and has locked in several other best bets that bring HUGE returns! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Fury vs. Wilder III on Saturday night? And which prop is a MUST-BACK? ... Join SportsLine here to see which bets you need to make for Saturday's big fight, all from the accomplished combat sports analyst who has been profitable every year!