An American Athletic battle is on tap between the Tulane Green Wave and the No. 14 Houston Cougars at 8 p.m. ET on Wednesday at Fogelman Arena in Devlin Fieldhouse. Tulane is 12-11 overall and 8-3 at home, while the Cougars are 22-4 overall and 6-2 on the road. Houston is ranked first in the American Athletic; Tulane is ranked third. 

The Cougars are favored by 8.5 points in the latest Tulane vs. Houston odds from Caesars Sportsbook, while the over-under is set at 137.5. Before you make any Houston vs. Tulane picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Tulane vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Tulane vs. Houston? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.