The Tennessee Titans (1-2) will travel to take on the Indianapolis Colts (1-1-1) in a key AFC South battle on Sunday at 1 p.m. ET. Both teams were winless through Week 2, but bounced back with much-needed victories in Week 3. Caesars Sportsbook lists Indianapolis as the 3.5 point favorite in the latest Titans vs. Colts odds, while the over/under is set at 43. 

Before making any Colt vs. Titans picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has simulated Titans vs. Colts 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits more than 50% of the time. You absolutely need to see it before locking in your own picks.

So who wins Titans vs. Colts? And which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.