The Buffalo Bills (1-0) will host the Tennessee Titans (0-1) on Monday Night Football. Kickoff is set for 7:15 p.m. ET from Highmark Stadium. Buffalo is a 10-point favorite in the latest Titans vs. Bills odds from Caesars Sportsbook, and the over/under for total points scored is 47.5. Before you make any Titans vs. Bills picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model knows Buffalo had a dominating performance in their Week 1 victory over the Los Angeles Rams. They were able to consistently move the ball, finishing with 413 total yards of offense. Quarterback Josh Allen went 26-of-31 for 297 yards with three passing touchdowns. In addition, he led the team with 56 rushing yards. 

The model also knows Tennessee will look to have an impactful rushing attack. This ground game is headlined by two-time Pro Bowler Derrick Henry. He's a strong and physical runner who owns the speed to break away from defenders. In Week 1, he logged 21 carries for 82 yards.

Now, it has set its sights on Titans vs. Bills. We can tell you the model is leaning Over the total, and it also says one side of the spread cashes well over 50% of the time! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins Titans vs. Bills on Monday Night Football? And which side of the spread cashes well over 50% of the time? Join SportsLine now to see which side of the Bills vs. Titans spread to back, all from the model that 's an amazing 139-98 on NFL picks!