The New York Giants hope to avoid their fifth consecutive 0-2 start to a season when they visit the NFC East-rival Washington Football Team on Thursday Night Football. Kickoff from FedEx Field in Landover, Maryland is set for 8:20 p.m. ET. Washington is a 3.5-point favorite in the latest Giants vs. Washington odds from Caesars Sportsbook, while the over-under for total points scored is 40.5.

New York is in danger of losing at least its first two games for the fifth straight year after opening the 2021 NFL season with a 27-13 home loss to Denver last Sunday. Daniel Jones threw for one touchdown and ran for another but lost a crucial fumble in the second half for his 40th turnover in his 28th career game. Saquon Barkley returned to action for the first time since suffering a torn ACL in Week 2 of the 2020 campaign and had 10 carries for 26 yards.

Washington also dropped its season-opener, losing a 20-16 decision to the Los Angeles Chargers. Washington, which allowed the Chargers to convert 14 of 19 third-down opportunities, held a three-point lead in the fourth quarter before succumbing. Taylor Heinicke will start for just the second time in 10 career NFL games as Ryan Fitzpatrick suffered a hip subluxation.

Before making any Washington vs. Giants picks or any other NFL Week 1 predictions, you NEED to see which side SportsLine expert Mike Tierney is on.

A national sportswriter whose work appears in The New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. 

He's used his experience to crush the NFL, going 187-147 against the spread the past three seasons. In addition, Tierney is an incredible 23-9-1 on his last 33 picks involving Washington. Anyone who has followed him is WAY UP.

Now, Tierney has locked in another confident against-the-spread pick for Giants vs. Washington. We can tell you he's leaning Under, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Giants vs. Washington on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Washington vs. Giants spread to jump on, all from the expert who's an eye-popping 23-9 on picks involving Washington!