The Green Bay Packers play the San Francisco 49ers in a primetime matchup on Sunday Night Football. Green Bay bounced back from their Week 1 blunder with a win at home against the Detroit Lions. The San Francisco 49ers are undefeated after back-to-back wins against the Detriot Lions and Philadelphia Eagles. Kickoff from Levi Stadium is at 8:20 p.m. ET. San Francisco is a three-point favorite in the latest Packers vs. 49ers odds from Caesars Sportsbook, while the Over-Under is 50.5.

Before you make any Packers vs. 49ers picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,800 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 3 of the 2021 season on an incredible 122-81 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows Niners receiver Deebo Samuel has been off to a hot start. Through two weeks, the South Carolina product leads the league in receiving yards. Samuel has hauled in 15 catches for 282 yards and one touchdown. The 2019 second-round pick is a legit deep threat, averaging 18.8 yards per reception. 

The model also knows Packers running back Aaron Jones bounced back after a disappointing Week 1 performance. The 2017 fifth-round pick did a lot of damage through the air, reeling in six catches for 48 yards and three touchdowns. His monster four-touchdown game showcased Jones' versatility.

Now, the model has set its sights on Packers vs. 49ers. We can tell you it's leaning Over on the total, and it also says one side of the spread has ALL the value! You ABSOLUTELY need to see it before locking in any NFL picks of your own.

So who wins 49ers vs. Packers on Sunday Night Football? And which side of the spread has ALL the value? ... Join SportsLine right now to see which side of the Packers vs. 49ers spread to back, all from the dialed-in NFL model that's up almost $8,000 on top-rated picks!