The Indianapolis Colts (2-4) will visit the San Francisco 49ers (2-3) on Sunday Night Football. The Colts steamrolled through the Houston Texans in a blowout 31-3 victory last week. The 49ers were on their bye in Week 6 and head into this matchup rested. Head coach Kyle Shanahan is optimistic that quarterback Jimmy Garoppolo will be ready to go as he returns from a calf injury. 

Kickoff from Levi's Stadium is set for 8:20 p.m. ET. San Francisco is favored by 3.5 points in the latest Colts vs. 49ers odds from Caesars Sportsbook, while the Over-Under is 41.5. Before making you make any Colts vs. 49ers picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,700 for $100 players on top-rated NFL pickssince its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 7 of the 2021 season on an incredible 125-85 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows Colts quarterback Carson Wentz has played well through the first six games of the year. Wentz has completed 64 percent of his passes for 1,545 yards with nine touchdowns to just one interception. In his last two games against the Houston Texans and Baltimore Ravens, Wentz has balled out. He went 36-of-55 for 625 yards with four total touchdowns and zero interceptions. 

The model also knows San Francisco receiver Deebo Samuel is one of the top threats in the league. Samuel is ranked fifth in the league with 548 receiving yards with three scores. The South Carolina product has reeled in eight passes of 20-plus yards downfield. Samuel also averages a team-high 17.7 yards per reception.

Now, the model has set its sights on Colts vs. 49ers. We can tell you it's leaning over the point total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any Colts vs. 49ers picks of your own.

So who wins 49ers vs. Colts on Sunday Night Football? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to see which side of the Colts vs. 49ers spread to back, all from the dialed-in NFL model that's up almost $8,000 on top-rated picks!