The ninth-ranked St. John's Red Storm look to win their 11th consecutive game when they battle the Villanova Wildcats in a key Big East Conference matchup on Wednesday night. St. John's is coming off a 68-62 win over Connecticut on Friday, while Villanova downed Xavier 80-68 on Sunday. The Red Storm (21-3, 12-1 Big East), who lead the conference, are 5-1 on the road this season. The Wildcats (14-10, 7-6 Big East), who are fifth in the league, are 11-3 on their home floor.

Tip-off from Finneran Pavilion in Villanova, Pa., is set for 6 p.m. ET. St. John's is a 2.5-point favorite in the latest St. John's vs. Villanova odds from SportsLine consensus, while the over/under for total points scored is 139.5.

Before making any St. John's vs. Villanova picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 15 of the 2024-25 season on a 211-154 roll (+2024) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated St. John's vs. Villanova 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that hits over 70% of the time!

So who wins St. John's vs. Villanova, and which side of the spread hits over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!