The Southern Miss Golden Eagles will take on the Liberty Flames at 7 p.m. ET on Saturday at Carlisle-Faulkner Field at M.M. Roberts Stadium. Liberty is coming off an 8-5 season and a bowl win, while the Golden Eagles were 3-9 last year, finishing last in the Conference USA West Division. 

The Flames are favored by 3.5 points in the latest Southern Miss vs. Liberty odds from Caesars Sportsbook, and the over-under is set at 49.5. Before you make any Liberty vs. Southern Miss picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Southern Miss vs. Liberty 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Liberty vs. Southern Miss? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!