The South Carolina Gamecocks will open the season against the No. 21 North Carolina Tar Heels on Saturday night in Charlotte. Two of the top returning quarterbacks in college football will square off in the Duke's Mayo Classic. North Carolina's Drake Maye was the ACC Player of the Year in 2022, while South Carolina's Spencer Rattler threw for more than 3,000 yards with 18 touchdowns.  

Kickoff is set for 7:30 p.m. ET on Saturday at Bank of America Stadium. The Tar Heels are favored by 2.5 points in the latest South Carolina vs. North Carolina odds, while the over/under is 63.5 points, per SportsLine consensus. 

Before entering any North Carolina vs. South Carolina picks, you NEED to see the college football predictions from the model at SportsLine.

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The model has simulated South Carolina vs. North Carolina 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits more than 50% of the time! You can only see the pick at SportsLine.

So who wins South Carolina vs. North Carolina, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.