The upstart Detroit Lions (1-0) are set to host the Seattle Seahawks (0-1) in a matchup of NFC teams with postseason aspirations on Sunday of the NFL Week 2 schedule. The Lions are looking to build off their upset 21-20 win over the defending Super Bowl champion Kansas City Chiefs in the NFL Kickoff Game, while the Seahawks are looking to bounce back from a 30-13 home blowout loss to the Los Angeles Rams in Week 1. 

Kickoff at Ford Field in Detroit is scheduled for 1 p.m. ET. Detroit is a 4.5-point favorite and the over/under for total points scored is 47 in the latest Lions vs. Seahawks odds.

Before making any Lions vs. Seahawks picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has set its sights on Seahawks vs. Lions. We can tell you the model is leaning Over on the point total, and it also says one side of the spread cashes in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Lions vs. Seahawks in Week 2 of the 2023 NFL season, and which side of the spread cashes well over 50% of the time? ... Join SportsLine right now to find out which side of the Seahawks vs. Lions spread is a MUST-BACK, all from the model on a 163-113 roll on NFL picks!