The San Francisco 49ers and the Seattle Seahawks are set to square off in a Week 14 NFC West battle on Sunday at Levi's Stadium. San Francisco is 9-3 overall and 4-1 at home, while Seattle is 6-6 overall and 2-4 on the road. Seattle is coming off a 41-35 loss to the Dallas Cowboys and will be looking to snap a three-game losing streak. The 49ers are looking to extend their winning streak to five games after notching a 42-19 blowout win over the Philadelphia Eagles in Week 13. 

Kickoff is at 4:05 p.m. ET. The Niners are favored by 13 points in the latest 49ers vs. Seahawks odds, and the over/under is set at 46.5 points. Before locking in any 49ers vs. Seahawks picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 14 of the 2023 NFL season on an incredible 176-128 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 30-20 roll on top-rated NFL picks since Week 7 of last season and is 31-12 straight-up the last three weeks. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The  model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins 49ers vs. Seahawks, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!