The UConn Huskies and the San Diego State Aztecs are set to battle it out on Thursday in a Sweet 16 matchup in the 2024 NCAA Tournament East Region. The Huskies, the top overall seed in the Tournament, reached the Sweet 16 by beating Stetson in the first round, and Northwestern in the second round. SDSU reached the Sweet 16 for the sixth time in program history be knocking off UAB in the first round and Yale in the second round. This will be a rematch of last year's national championship game. 

Tipoff is set for 7:39 p.m. ET from the TD Garden in Boston. The Huskies are 12-point favorites in the latest UConn vs. San Diego State odds via SportsLine consensus after opening as 10.5-point favorites, while the over/under is up to 136.5 points after opening at 135.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any San Diego State vs. UConn picks, you need to check out the college basketball predictions and betting advice from the SportsLine expert Jimmie Kaylor.

Kaylor is a betting and DFS expert for SportsLine, who has covered college sports and the NFL for close to a decade as a member of the Pro Football Writers of America. His background as a former high level athlete -- he was a Division-I All-American and professional athlete -- gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college basketball landscape and has been cashing in big for SportsLine members for the last two years. 

Kaylor enters the Sweet 16 round on a 22-10 run overall on his college basketball picks, with a 7-2 record on 2024 NCAA Tournament picks for SportsLine. He is up 11.05 units, returning a profit of $1,105 for $100 bettors. Anyone who has followed his picks is way up!

Now, Kaylor has locked in a confident against-the-spread pick for UConn vs. San Diego State in the Sweet 16 round of the 2024 NCAA Tournament. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own. 

Who wins UConn vs. San Diego State, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the proven expert who has been cashing BIG for SportsLine members for the last two years!