The New Orleans Saints look for a Week 1 victory at home as they host NFC South Division rival, the Carolina Panthers on Sunday afternoon. New Orleans tied for the division lead at 9-8 last season but lost the tiebreaker to Tampa Bay and missed the playoffs. Carolina was a league-worst 2-15 and starts a new era with head coach Dave Canales. New Orleans won both meetings last season: 20-17 and 28-6. 

Kickoff from the Caesars Superdome is set for 1 p.m. ET. The Saints are 3.5-point favorites in the latest Saints vs. Panthers odds, while the over/under for total points is 41.5. The Saints are -196 money-line favorites, while the Panthers are +163 underdogs. Before making any Saints vs. Panthers picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 181-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 35-21 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated Saints vs. Panthers 10,000 times and the results are in. We can tell you the model is leaning Over on the total. It also says one side of the spread cashes in more than 70% of simulations! You ABSOLUTELY need to see what it is before locking in any NFL picks of your own!

Who wins Saints vs. Panthers, and which side of the spread cashes in over 70% of simulations? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!