A Week 2 NFC South battle is on tap between Jameis Winston and the New Orleans Saints and Tom Brady and the Tampa Bay Buccaneers at 1 p.m. ET on Sunday at Caesars Superdome in New Orleans. The Saints opened the 2022 NFL season with a come from behind 27-26 win over the Atlanta Falcons, while the Buccaneers dominated the Dallas Cowboys 19-3 on Sunday Night Football. The Saints won both matchups against the Buccaneers in 2021. 

Tampa Bay is favored by 2.5 points in the latest Saints vs. Buccaneers odds from Caesars Sportsbook, and the over/under is set at 44. Before you make any Buccaneers vs. Saints picks, you need to see the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Saints vs. Buccaneers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Saints vs. Buccaneers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!