The Houston Astros will look to continue their recent mastery over the Colorado Rockies when they meet in an interleague matchup on Wednesday afternoon. Houston has won 12 of the past 14 matchups with Colorado since 2018. The Rockies (33-54), who are 4-6 in their last 10 games, are just 13-30 away from home in 2023. The Astros (48-38), who have won seven of 10, are 23-19 on their home field this year.

First pitch from Minute Maid Park in Houston is set for 2:10 p.m. ET. The Astros are the -235 favorites on the money line (risk $235 to win $100) in the latest Rockies vs. Astros odds from Caesars Sportsbook, while the over/under for total runs scored is 9 (see the latest lines for every game on our MLB odds page).

Before making any Rockies vs. Astros picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has excelled on top-rated run-line picks this season, going 11-2 (+604). Anybody following has seen big returns!

The model knows Houston right fielder Kyle Tucker has been on a tear. He has hits in 11 consecutive games, including a 4-for-4, one double, one homer and four RBI performance in Monday's 12-11 win at Texas. He was 1-for-5 in Tuesday's win over Colorado. For the season, Tucker is batting .293 with 19 doubles, 13 homers, 55 RBI and 45 runs scored.

The model also knows Colorado shortstop Ezequiel Tovar has been hot of late and had a 15-game hitting streak snapped on Tuesday. He had six multi-hit games during that stretch, including a 2-for-4, one homer and three RBI performance in an 8-5 win over Detroit on Friday. In 80 games this season, he is hitting .266 with 20 doubles, two triples, eight homers, 41 RBI and 40 runs scored. His best game came in a 5-2 win at New York against the Mets on May 6. He was 3-for-4 with a double, homer and two RBI with two runs scored.

Now, it has set its sights on Rockies vs. Astros. We can tell you the model is leaning Under on the total, projecting 8.9 combined runs, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Rockies vs. Astros? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Rockies vs. Astros money line you should be all over on Wednesday, all from the model that is 11-2 this season on top-rated run-line picks (+604) this season!