An NFC West contest on Monday Night Football features the Los Angeles Rams (2-1) against the San Francisco 49ers (1-2). Kickoff is set for 8:15 p.m. ET from Levi's Stadium. San Francisco is a two-point favorite in the latest Rams vs. 49ers odds from Caesars Sportsbook, and the over/under for total points scored is 42.5.

Before making any Rams vs. 49ers picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows San Francisco has been playing dominant and grueling defense thus far. This group is physical and fast, with the numbers to back that up. They are second in total yards allowed (227), first in passing yards allowed (148.3), and fourth in rushing yards allowed (78.7). Linebacker Dre Greenlaw is consistently around the ball, leading the team in total tackles (23). 

The model also knows Los Angeles receiver Cooper Kupp is a supreme route technician with excellent short-area agility. Kupp knows how to gain separation from defenders and create a throwing window. The 2021 Pro Bowl selection is second in receptions (28), eighth in receiving yards (280) and tied for second in receiving touchdowns (3).

Now, the model has set its sights on Rams vs. 49ers on Monday Night Football. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins Rams vs. 49ers on Monday Night Football? And which side of the spread hits well over 50% of the time? Join SportsLine now to see which side of the Rams vs. 49ers spread to back, all from the model that 's an amazing 139-103 on NFL picks!