It's expected to be a slug-fest on Saturday when Big Ten foes face off with the third-ranked Iowa Hawkeyes (5-0) hosting the No. 4 Penn State Nittany Lions at Kinnick Stadium in Iowa City. Kickoff is set for 4 p.m. ET. 

The Hawkeyes are 2.5-point favorites in the latest Penn State vs. Iowa odds from Caesars Sportsbook, while the over-under for total points scored is 41. (See the latest college football lines for all of this week's games on our college football odds page.)

Before making any Penn State vs. Iowa picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The Hawkeyes defense has carried the team so far. It ranks second in scoring (11.6 points per game) and seventh in total yards allowed (271.4). It also has forced 16 turnovers, tied for most in the nation, with 12 interceptions by eight different players. The Iowa offense averages just 320 total yards (119th), but it is still averaging more than 33 points per game and has turned it over just four times. 

Penn State's defense ranks third in the nation in allowing just 12 points per contest and yields 313.4 yards per game (33rd). It faces an Iowa offense that is 96th in FBS in passing and 99th in rushing. The Hawkeyes have lived on turnovers, but the Nittany Lions have given the ball away just four times. QB Sean Clifford has been efficient, throwing for 1,336 yards with 11 TDs and three interceptions. 

Now the model has simulated Penn State vs. Iowa 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread hits in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the battle between Penn State vs, Iowa on Saturday? And which side of the spread hits in well over 60 percent of simulations? ... Join SportsLine right now to see which side of the Penn State vs. Iowa spread you need to jump on Saturday, all from the computer model on a 12-4 run on its top-rated college football side picks!