An NFC South battle is on tap between the Carolina Panthers and the Tampa Bay Buccaneers at 1 p.m. ET next Sunday at Bank of America Stadium. Carolina is 5-9 overall and 2-5 at home, while Tampa Bay is 10-4 overall and 4-3 on the road. 

Tampa Bay is favored by 10 points in the latest Panthers vs. Buccaneers odds from Caesars Sportsbook, and the over-under is set at 43. Before you make any Buccaneers vs. Panthers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

Now, it has simulated Panthers vs. Buccaneers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins Panthers vs. Buccaneers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!