The Colorado Buffaloes' Deion Sanders-led turnaround faces a major challenge on Saturday when the No. 19 Buffaloes hit the road to face the No. 10 Oregon Ducks at Autzen Stadium in Eugene, Ore. One year after the team went 1-11 and fired coach Karl Dorrell, Sanders and the Buffaloes (3-0) have become the biggest story of all of college football. Meanwhile the Ducks (3-0) are off to a 3-0 start for the fifth time since 2017.

Kickoff is scheduled for 3:30 p.m. ET. The Ducks are 21-point favorites in the latest Oregon vs. Colorado odds, while the over/under for total points scored is 70. (See up-to-date odds for every game this week on our college football odds page.)

Before you make any Colorado vs. Oregon picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns!

The model knows that Oregon has an experienced and prolific quarterback in Bo Nix. A fifth year senior who's in his second season in Eugene, Nix leads all active FBS quarterbacks with 50 career starts and ranks second in total offense (13,176 yards). This season he ranks 12th in the country in passing yards per game (297.7).

The model also knows that Buffaloes quarterback Shedeur Sanders has been lights-out to start the season. One of five children of coach Deion Sanders, the younger Sanders leads the country in completions per game (35.7) and ranks second in total offense (397.3 yards per game) and passing yards per game (417.0). Last week he made several clutch throws late in regulation and in overtime to rally Colorado to a 43-35 win over Colorado State.

Now, the model has set its sights on Oregon vs. Colorado. We can tell you it is leaning Under the total, projecting the teams to combine for 65 points, and it also says one side of the spread hits in more than 60% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Colorado vs. Oregon? And which side of the spread hits in more than 60% of simulations? ... Join SportsLine right now to find out which side of the Oregon vs. Colorado spread you should be all over Saturday, all from the model that's up nearly $2,500 on top-rated CFB spread picks since its inception!