The No. 25 Oregon Ducks will take on the No. 12 BYU Cougars at 3:30 p.m. ET on Saturday at Autzen Stadium. BYU is looking to build off its 26-20 win over then-No. 9 Baylor in overtime last weekend. The Ducks are favored by 3.5 points in the latest Oregon vs. BYU odds from Caesars Sportsbook, while the over/under is set at 58. 

Before you make any BYU vs. Oregon picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Oregon vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Oregon vs. BYU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.