A Pac-12 battle is on tap between the Oregon Ducks and the Arizona Wildcats at 10:30 p.m. ET on Saturday, September 25 at Autzen Stadium. No. 3 Oregon is 3-0 overall and 2-0 at home, while Arizona is winless in 2021. This is the Pac-12 conference opener for both teams.

Oregon is favored by 28 points in the latest Oregon vs. Arizona odds from Caesars Sportsbook, and the over-under is set at 58. Before you make any Arizona vs. Oregon picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Oregon vs. Arizona 10,000 times and the results are in. We can tell you that the model is leaning under for the point total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Oregon vs. Arizona? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!