It's a battle of unbeaten teams on Saturday afternoon when the No. 1 Alabama Crimson Tide host the 12th-ranked Ole Miss Rebels in the SEC on CBS matchup at Bryant-Denny Stadium. The Crimson Tide are 4-0, while Ole Miss has dominated all three of its games, but Alabama has won five straight meetings and is 52-10-2 all-time against the Rebels.

Kickoff is set for 3:30 p.m. ET in Tuscaloosa, Ala. The Tide are the 15-point favorites in the latest Ole Miss vs. Alabama odds from Caesars Sportsbook, while the over-under for total points scored is 79.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you make any Alabama vs. Ole Miss picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on a 81-61 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

The Crimson Tide have already faced a test this season, beating current No. 10 Florida 31-29 on Sept. 18. Sophomore quarterback Bryce Young has passed for 1,124 yards and 15 TDs, with just one interception, in the first four games. He leads an offense that averages 46.5 points, fourth-most in the nation. The Tide defense ranks 17th in total yards allowed (283.8 per game)      

The Rebels offense leads FBS in total yards (635.3 per game) and scoring (52.7 points), and they are outscoring opponents by 32 per contest. They also rank fourth in rushing, putting up 298.7 yards per game. Ole Miss quarterback Matt Corral has moved to the center of the Heisman discussion with just shy of 1,000 yards, nine touchdowns and no picks in their three matchups.          

Now the model has simulated Mississippi vs. Alabama 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread hits in 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the battle between Mississippi vs. Alabama on Saturday? And which side of the spread hits in 60 percent of simulations? ... Join SportsLine right now to see which side of the Alabama vs. Mississippi spread you need to jump on Saturday, all from the computer model on a 81-61 run on its college football picks!