A Big 12 battle is on tap between the No. 4 Oklahoma Sooners and the TCU Horned Frogs at 7:30 p.m. ET on Saturday at Gaylord Family-Oklahoma Memorial Stadium. Oklahoma is 6-0 overall and 4-0 at home, while TCU is 3-2 overall and 1-0 on the road. 

The Sooners are ranked first in the Big 12; the Horned Frogs are ranked fifth. The Sooners are favored by 13.5 points in the latest Oklahoma vs. TCU odds from Caesars Sportsbook, and the over-under is set at 64. Before you make any TCU vs. Oklahoma picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Oklahoma vs. TCU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Oklahoma vs. TCU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!