The Oklahoma State Cowboys and No. 25 Kansas State Wildcats begin their Big 12 conference play with a 7 p.m. ET showdown on Saturday at Boone Pickens Stadium. The Cowboys are 3-0 after a trio of close wins to start the season, and K-State is also undefeated through its first three games. 

Oklahoma State is 2-0 at home, while K-State is gearing up for it first road game of 2021. The Wildcats have been strong in run defense, and have allowed just 54.7 opposing rushing yards per game. They'll be tested by Cowboys running back Jaylen Warren, who is averaging 5.1 yards per carry this season. The Cowboys are favored by six points in the latest Oklahoma State vs. Kansas State odds from Caesars Sportsbook, and the over-under is set at 45. Before you make any Kansas State vs. Oklahoma State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Oklahoma State vs. Kansas State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Oklahoma State vs. Kansas State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks ... If you're already a member, see the picks below!