An ACC battle is on tap between the Notre Dame Fighting Irish and the No. 25 Pittsburgh Panthers at 7 p.m. ET on Wednesday at Purcell Pavilion at the Joyce Center. Pittsburgh can clinch at least a share of the ACC regular-season title with a win in this game. The Panthers are favored by 4.5 points in the latest Notre Dame vs. Pittsburgh odds from Caesars Sportsbook, while the over/under is set at 142. 

Before you make any Pittsburgh vs. Notre Dame picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 17 of the season 76-46 on all-top rated college basketball picks this season, returning more than $1,600 for $100 players. Anybody who has followed it has seen huge returns.

Now, it has simulated Notre Dame vs. Pittsburgh 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Notre Dame vs. Pittsburgh? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!