Two strong contenders to make the College Football Playoff collide when the No. 3 Ohio State Buckeyes and No. 12 Oregon Ducks square off in a marquee matchup on Saturday at Ohio Stadium in Columbus, Ohio. Kickoff is at noon ET. The Buckeyes are 14.5-point favorites in the latest Ohio State vs. Oregon odds from Caesars Sportsbook, while the over-under for total points scored is 64. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you make any Oregon vs. Ohio State picks and college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of more than $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Ohio State has one of the best receivers in the country in Chris Olave. A first-team AP preseason All-America receiver, Olave opened the season with a big performance, making four catches for 117 yards and two touchdowns against the Golden Gophers. His touchdowns covered 38 and 61 yards.

But Oregon has a potent running back duo in CJ Verdell and Travis Dye. Both juniors, Verdell and Dye have the most combined career rushing yards (4,501) of any active FBS running back tandem. In the season-opening win over Fresno State, the two combined for 138 rushing yards and two touchdowns on 31 carries.

Now the model has simulated Ohio State vs. Oregon 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it has generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the battle between Ohio State and Oregon? And which side of the spread hits in over 50 percent of simulations? ... Join SportsLine right now to see which side of the Oregon vs. Ohio State spread you need to jump on Thursday, all from the computer model that has crushed its college football picks!